According cording to a recent report by Verified Market Research, the Global Chiral Chemicals market is anticipated to reach USD 133.2 billion by 2026, registering at a CAGR of 13.9 per cent during the forecast period. Chiral technology has observed significant growth in recent years, and the development of chiral chemicals have become faster and more cost-effective with the development of advanced manufacturing and analytical methods. The most significant increase in the application of chiral molecules (especially enantiomers) has been in the development of new drugs by the pharmaceutical industry. This is substantiated by the fact that majority of drugs approved by the US FDA and other regulatory bodies around the world, in recent times, are chiral molecules. For example, eleven out of twenty-one antiepileptic drugs (AED’s)introduced into the global market between 1989and 2021, are chiral molecules. Nine of these are single isomers.
This is primarily because individual enantiomers (enantiopure drugs) exhibit marked differences in pharmacodynamic, pharmacokinetic, and toxicological properties compared to their racemic or non-chiral analogues via (a) an improved therapeutic index through increased potency and selectivity and decreased side-effects; (b) a faster onset of action; (c) a reduced propensity for drug-drug interactions, and (e) a lower dosage requirement. For example, in the figure below, (R,R) and (S,S) Ethambutol are diastereomers (or non-super imposable mirror images) of each other. (R,R)-Ethambutol causes blindness, whereas (S,S)-Ethambutol can be used to treat tuberculosis. Moreover, advances in industrial chemical processes, and the US FDA policy statement of 1992, provide additional incentives to develop enantiopure drugs even though they were initially marketed as a racemate. Apparently, images matter! mirror images, even more!
Founded with the tagline of images matter! mirror images, even more! and with the sole purpose of being the most preferred supplier of chiral or achiral homogeneous precious metal catalysts, chiral ligands, API Intermediates, and speciality chemicals is Bulandshahar based Synthesis with Catalysts Pvt Ltd (SWC). It caters to customers from a wide range of industries including the aroma chemicals, essential oils, pharmaceuticals, and API industry. As the largest manufacturer of asymmetric catalysts, ligands in the country, SWC's aim is to meet customer requirements by leveraging the range of services or products offered by the company.
Focus On Quality
Providing customers with high-quality products, at optimum costs, faster delivery lead times, and a wide range of exceptional services has endeared Synthesis with Catalysts to its customers, allowing it to become one of the most preferred suppliers of chiral or achiral homogeneous precious metal catalysts, chiral ligands, API intermediates, and specialty chemicals in the country..
20215While Synthesis with Catalysts is into the development and manufacturing of asymmetric/achiral precious metal catalysts, the company also offers pre-catalyst intermediates and chiral ligands in order to provide its clients with a greater degree of freedom and allows them to make their own catalyst recipe. Based on specific request on catalyst selection SWC offers inputs/suggestions based on the expertise of its learned R&D team. The catalysts, ligands, and processes developed have applications in several industries including the active pharmaceutical ingredient (API), agrochemicals, aroma chemicals, bulk chemicals, essential oils, flavours, fragrances, fine chemicals, pharma products, and specialty chemicals industry.
Lower Cost& Faster Delivery
Customers today expect consistent delivery of the product within the stipulated timelines, at the required quality, and optimum cost. More than 95 per cent of SWC’s raw materials are sourced from domestic manufacturers and suppliers. SWC’s rapid sourcing of raw materials, combined with its mantra of continuous improvement, has helped the organization to manufacture quality products, at lower production costs and faster delivery timelines. All this is possible only because of the SWC team which consists of highly qualified and experienced scientists and technologists who are constantly looking to improve the products and processes, develop technologies and meet customer requirements through consulting.
Wide Range Of Solutions
SWC offers a wide range of products and services that include homogeneous precious metal catalysts of ruthenium, rhodium, palladium, platinum, and iridium, Jacobsen’s type, and other homogeneous catalysts of cobalt, manganese, aluminium, iron, chromium, zinc, nickel, copper, iron, yttrium, and titanium. Other products include chiral auxiliaries, & ligands, API intermediates, and specialty chemicals (chiral alcohols). SWC also provides custom design, custom synthesis, custom manufacturing and consultancy services for project management, process, and product development including scale-up, and cost-benefit analysis.
People-Centricity
Synthesis with Catalysts is a people-centric company and places a high emphasis on people-to-people interaction. “We are easily accessible to our customers and our people-centric approach coupled with an exceptional range of products and services is what differentiates us from other products in this segment,” affirms Axay Parmar, Founder & CMD, Synthesis with Catalysts Pvt. Ltd.
The Driving Force
The SWC team consists of highly cited, renowned, and well-experienced scientists, technologists, and professionals who have more than 600 publications, patents, and research articles to their credit. They are the driving forces that enable SWC to manufacture and supply its catalysts and ligands in the highest achievable purities, along with providing exceptional levels of services for its customers. SWC is a one-stop resource for all requirements related to chiral catalysts, ligands, processes, technologies, or products. The company prides itself on being able to develop the simplest, most inexpensive, and most optimized process to manufacture its products.
Leveraging Improvement Opportunities
To stay ahead of the competition, and to provide its customers with high-quality products and exceptional services, the technical team at Synthesis with Catalysts are always on the lookout for improvement opportunities, be it in terms of improving yield or selectivity to the desired product, cycle time reduction (manufacture), or reducing the environmental burden of the process. The research team at SWC is constantly looking at alternate routes to manufacture the same products, which could lead to the aforementioned benefits.
“We have a dynamic team that continuously monitors literature, performs market research to stay abreast of the latest developments in our areas of interest. Our vibrant R&D and technology teams are continuously working to develop new products and processes or improve the current offerings,” says Axay Parmar. “We solicit and value customer feedback and leverage the latest technologies in manufacturing, QC/QA, CRM and data analysis to meet customer requirements,” he adds.
Fully Automatic Manufacturing Plants
All production activities of Synthesis with Catalysts are carried out in fully automatic manufacturing plants and follow strict quality control protocols. While SWC’s manufacturing plants are supported by well-equipped quality control labs having the latest analytical instruments, the research and application development labs develop new products for the company to support process related troubleshooting activities.
“We are governed by a robust quality management protocol that includes visual management and lean principles. We follow ISO and GMP like processes to maintain the strict quality standards required by our customers. We are a zero-discharge facility and ensure the minimal environmental impact of our operations,” explains AxayParmar.
Synthesis is governed by a robust quality management protocol that includes visual management and lean principles
The Journey
Established in 2015 with a vision to be one of the most respected, and the best catalyst manufacturing companies in the country, Synthesis with Catalysts Private Limited (SWC) has seen a gradual growth over the years, and its turnover has increased from INR 1.26 crores in 2018-19 to 45 crores in 2021-22 (projected). Based on current projections, SWC is expected to have a turnover of INR 190 crores by 2025-26. The company has seen a gradual increase in the number of clients from 2019 and has increased its geographical presence. SWC has a sales office in the USA and has catered to clients in the USA, South America, Europe, and Asia.
Team SWC consists of highly cited, renowned, and well-experienced scientists and technologists who not only innovate and develop new products for the company, but also help their customers improve their offerings by providing technical assistance in their catalyst, chemistry, or process development projects. The state-of-the-art research and application development labs, pilot plants, and production facilities, all supported by a well-equipped, advanced analytical testing lab are enablers that allow SWC to succeed in this journey of innovation, product development, process intensification, and customer service.
The Road Ahead
The current operations of Synthesis with Catalysts are out of leased facilities and therefore it has limited manufacturing capacity. However, the company has acquired land and construction work on a new manufacturing facility in Sikandrabad, UP is currently in progress. The facility is expected to become operational by the end of the year (2021) and provide expanded manufacturing to the company. This facility will house state of the art R&D labs, application development labs, pilot plants, manufacturing plants, and well-equipped analytical labs for quality control. This will provide the much-required, additional manufacturing and analytical capability and allow for expansion of the range of products and services offered.
Imparting Knowledge To The Next Generation
SWC participates in a host of CSR activities like working closely with local NGO’S on running community kitchens, clothes distribution, and tree plantation programs. SWC intends to play its part in employment generation by providing jobs to suitably qualified local candidates in its new manufacturing capacity. SWC has a team of well-qualified scientists and technologists who would like to pass on their knowledge to the next generation. In the next few years, SWC would like to set up a skill development and training centre to impart knowledge and train young researchers and analysts in the use of modern analytical instruments and techniques.
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