The research conducted by Prof. Shulamit Levenberg's group at the Technion Faculty of Biomedical Engineering represents a significant advancement in drug delivery and tissue implantation techniques aided by ultrasound technology. Published in the journal Small Methods, their work introduces a non-invasive method for bio-printing live cells and tissues deep within the body using external sound wave irradiation.
Traditionally, many biomedical procedures requiring precise delivery of biocompatible materials involve invasive surgeries, which pose risks such as infection, tissue damage, and lengthy recovery times. The researchers' innovative approach aims to overcome these challenges by delivering cells or drugs directly to the targeted area deep within the body through injection or catheterization of a biological fluid ink.
Following the delivery of the desired materials, engineered tissue is printed using sound waves emitted from an external ultrasonic transducer. This method enables the construction of engineered tissue deep within the body without exposing the treated site to invasive procedures.
The versatility of this technology is demonstrated in various applications, including local cell transplantation, continuous localized drug delivery, and three-dimensional bioprinting. Importantly, the mechanical properties of the grafts can be customized to match the characteristics of the target tissue and achieve the desired drug release rate.
Overall, this innovative approach represents a significant step forward in biomedical engineering, offering a promising solution for precise and minimally invasive tissue engineering and drug delivery procedures.
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